Bone Abstracts

The close relationship between muscle and bone has long been recognized especially during development where one tissue does not develop in the absence of the other. The mechanical interactions between the two tissues have dominated research under the assumption that the major interaction between the two tissues was the loading/unloading of bone by muscle. Though clear that loading of bone by muscle is necessary to maintain healthy bone, the concept that bone could have positiv...

Biographical DetailsDr Lynda F Bonewald is a University of Missouri, Kansas City (UMKC) Curators Professor, the Lefkowitz Professor of Oral and Craniofacial Sciences, and Director of the Mineralized Tissue/Bone Biology Research Program at the UMKC School of Dentistry, Director of the UMKC Center of Excellence in the Study of Dental and Musculoskeletal Tissues and UMKC Vice Chancellor for ...

Osteoporosis is a frequent disease leading to an increased risk of fractures caused by a systemic impairment of bone mass, strength, and microarchitecture. Given the emerging role of the Wnt signaling pathway in bone biology, we focused on the function of the important Wnt inhibitor dickkopf-1 (Dkk-1) and examined how the deletion of Dkk-1 solely in osteoblasts or osteocytes influences bone homeostasis. Therefore, we used the Cre-LoxP recombination system and crossed Dkk-1-flo...